Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc06057a Click here for additional data file.
نویسندگان
چکیده
Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.
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Integration of G-quadruplex and DNA-templated Ag NCs for nonarithmetic information processing† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00361g Click here for additional data file.
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Chiral tether-mediated stabilization and helix-sense control of complementary metallo-double helices† †Electronic supplementary information (ESI) available: Experimental details and additional spectroscopic data. See DOI: 10.1039/c4sc02275k Click here for additional data file.
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Transformable H-bonds and conformation in compressed glucose† †Electronic supplementary information (ESI) available: Detailed experimental data; detailed structural data. CCDC 1033994–1034008. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03588g Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.
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A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc08492c Click here for additional data file.
Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.
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